ASIC1

ASIC1
Identifiers
Aliases	ASIC1, ACCN2, ASIC, BNaC2, acid sensing ion channel subunit 1
External IDs	MGI: 1194915 HomoloGene: 121755 GeneCards: ASIC1
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.12 Start 50,057,548 bp End 50,083,611 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 F1 Start 99,670,718 bp End 99,701,127 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • ion gated channel activity • sodium channel activity • ion channel activity • protein binding • cation channel activity • ligand-gated sodium channel activity • acid-sensing ion channel activity Cellular component • integral component of membrane • membrane • synapse • integral component of plasma membrane • cell surface • Golgi apparatus • plasma membrane Biological process • negative regulation of neurotransmitter secretion • associative learning • sodium ion transmembrane transport • sodium ion transport • regulation of membrane potential • cation transport • memory • sensory perception of sour taste • ion transport • protein homotrimerization • ion transmembrane transport • cellular response to pH • calcium ion transmembrane transport • response to pH • signal transduction • response to acidic pH • calcium ion transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	41	11419
Ensembl	ENSG00000110881	ENSMUSG00000023017
UniProt	P78348	Q6NXK8
RefSeq (mRNA)	NM_001095 NM_001256830 NM_020039	NM_001289791 NM_009597
RefSeq (protein)	NP_001086 NP_001243759 NP_064423	NP_001276720 NP_033727
Location (UCSC)	Chr 12: 50.06 – 50.08 Mb	Chr 12: 99.67 – 99.7 Mb
PubMed search

41

11419

ENSG00000110881

ENSMUSG00000023017

P78348

Q6NXK8

NM_001095
NM_001256830
NM_020039

NM_001289791
NM_009597

NP_001086
NP_001243759
NP_064423

NP_001276720
NP_033727

Acid-sensing ion channel 1 (ASIC1) also known as amiloride-sensitive cation channel 2, neuronal (ACCN2) or brain sodium channel 2 (BNaC2) is a protein that in humans is encoded by the ASIC1 gene. The ASIC1 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 1996. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

...
Wikipedia