ASH1L

ASH1L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MQM, 3OPE, 4YNM, 4YNP, 4YPA, 4YPE, 4YPU
Identifiers
Aliases	ASH1L, ASH1, ASH1L1, KMT2H, ASH1 like histone lysine methyltransferase
External IDs	MGI: 2183158 HomoloGene: 10225 GeneCards: ASH1L
Gene ontology Molecular function • methyltransferase activity • transferase activity • DNA binding • chromatin binding • histone methyltransferase activity (H3-K4 specific) • metal ion binding • histone methyltransferase activity (H3-K36 specific) • histone-lysine N-methyltransferase activity Cellular component • Golgi apparatus • bicellular tight junction • chromosome • cell junction • extracellular exosome • nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • negative regulation of acute inflammatory response • histone H3-K36 dimethylation • interleukin-6 production • cell-cell signaling • DNA packaging • transcription from RNA polymerase II promoter • negative regulation of I-kappaB kinase/NF-kappaB signaling • transcription, DNA-templated • histone H3-K4 methylation • methylation • negative regulation of MAPK cascade • negative regulation of inflammatory response • positive regulation of transcription from RNA polymerase II promoter • covalent chromatin modification • skeletal system development • single fertilization • post-embryonic development • regulation of gene expression • decidualization • sebaceous gland development • uterus morphogenesis • sperm motility • tarsal gland development • uterine gland development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55870	192195
Ensembl	ENSG00000116539	ENSMUSG00000028053
UniProt	Q9NR48	Q99MY8
RefSeq (mRNA)	NM_018489	NM_138679
RefSeq (protein)	NP_060959	NP_619620
Location (UCSC)	Chr 1: 155.34 – 155.56 Mb	Chr 3: 88.95 – 89.08 Mb
PubMed search

3MQM, 3OPE, 4YNM, 4YNP, 4YPA, 4YPE, 4YPU

55870

192195

ENSG00000116539

ENSMUSG00000028053

Q9NR48

Q99MY8

NM_018489

NM_138679

NP_060959

NP_619620

ASH1L (also called huASH1, ASH1, ASH1L1, ASH1-like, or KMT2H) is a histone-lysine N-methyltransferase enzyme encoded by the ASH1L gene located at chromosomal band 1q22. ASH1L is the human homolog of Drosophila Ash1 (absent, small, or homeotic-like).

Ash1 was discovered as a gene causing an imaginal disc mutant phenotype in Drosophila. Ash1 is a member of the trithorax-group (trxG) of proteins, a group of transcriptional activators that are involved in regulating Hox gene expression and body segment identity. Drosophila Ash1 interacts with trithorax to regulate ultrabithorax expression.

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Wikipedia