ARNT2

ARNT2
Identifiers
Aliases	ARNT2, WEDAS, bHLHe1, aryl hydrocarbon receptor nuclear translocator 2
External IDs	MGI: 107188 HomoloGene: 7230 GeneCards: ARNT2
Gene ontology Molecular function • DNA binding • protein dimerization activity • transcription factor activity, sequence-specific DNA binding • aryl hydrocarbon receptor binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • protein binding • protein heterodimerization activity Cellular component • cytoplasm • transcription factor complex • nucleus • nucleoplasm Biological process • response to estradiol • response to hypoxia • regulation of transcription, DNA-templated • negative regulation of apoptotic process • in utero embryonic development • transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of transcription, DNA-templated • central nervous system development • brain development • positive regulation of cell proliferation • xenobiotic metabolic process • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9915	11864
Ensembl	ENSG00000172379	ENSMUSG00000015709
UniProt	Q9HBZ2	Q61324
RefSeq (mRNA)	NM_014862	NM_007488
RefSeq (protein)	NP_055677 NP_055677.3	NP_031514
Location (UCSC)	Chr 15: 80.4 – 80.6 Mb	Chr 7: 84.25 – 84.41 Mb
PubMed search

9915

11864

ENSG00000172379

ENSMUSG00000015709

Q9HBZ2

Q61324

NM_014862

NM_007488

NP_055677
NP_055677.3

NP_031514

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.

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