ARHGEF4

ARHGEF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DX1, 2PZ1, 3NMX, 3NMZ
Identifiers
Aliases	ARHGEF4, ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4
External IDs	MGI: 2442507 HomoloGene: 49414 GeneCards: ARHGEF4
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • protein binding • protein domain specific binding • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity Cellular component Biological process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50649	226970
Ensembl	ENSG00000136002	ENSMUSG00000037509
UniProt	Q9NR80	Q7TNR9
RefSeq (mRNA)	NM_015320 NM_032995	NM_183019
RefSeq (protein)	NP_056135 NP_127462	NP_898840
Location (UCSC)	Chr 2: 130.84 – 131.05 Mb	Chr 1: 34.68 – 34.81 Mb
PubMed search

2DX1, 2PZ1, 3NMX, 3NMZ

50649

226970

ENSG00000136002

ENSMUSG00000037509

Q9NR80

Q7TNR9

NM_015320
NM_032995

NM_183019

NP_056135
NP_127462

NP_898840

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants that encode different isoforms. Also, there is possibility for the usage of multiple polyadenylation sites for this gene.

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