ARHGAP4

ARHGAP4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2EPD
Identifiers
Aliases	ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115, Rho GTPase activating protein 4
External IDs	MGI: 2159577 HomoloGene: 20403 GeneCards: ARHGAP4
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 153,907,367 bp End 153,934,999 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A7.3 Start 73,891,442 bp End 73,921,870 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rac GTPase binding • protein binding • SH3/SH2 adaptor activity • GTPase activator activity Cellular component • cytosol • Golgi apparatus • growth cone • microtubule • cytoplasm Biological process • negative regulation of fibroblast migration • nervous system development • positive regulation of GTPase activity • negative regulation of cell migration • cytoskeleton organization • Rho protein signal transduction • regulation of small GTPase mediated signal transduction • negative regulation of axon extension • signal transduction • positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	393	171207
Ensembl	ENSG00000089820	ENSMUSG00000031389
UniProt	P98171	n/a
RefSeq (mRNA)	NM_001666 NM_001164741	NM_001162423 NM_001162424 NM_138630
RefSeq (protein)	NP_001158213 NP_001657	n/a
Location (UCSC)	Chr X: 153.91 – 153.93 Mb	Chr X: 73.89 – 73.92 Mb
PubMed search

2EPD

393

171207

ENSG00000089820

ENSMUSG00000031389

P98171

n/a

NM_001666
NM_001164741

NM_001162423
NM_001162424
NM_138630

NP_001158213
NP_001657

n/a

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene. It has been shown to regulate cell motility and axonal outgrowth in vitro.

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