APOA1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1AV1, 1GW3, 1GW4, 1ODP, 1ODQ, 1ODR, 2A01, 3K2S, 3R2P, 2MSC, 2MSD, 2MSE, 4V6M

Identifiers

Aliases

APOA1, entrez:335, apo(a), apolipoprotein A1, Apolipoprotein A-I

External IDs

OMIM: 107680 MGI: 88049 HomoloGene: 47900 GeneCards: APOA1

Genetically Related Diseases

Gene ontology
Molecular function	• lipase inhibitor activity • phosphatidylcholine binding • apolipoprotein receptor binding • high-density lipoprotein particle receptor binding • lipoprotein particle binding • phosphatidylcholine-sterol O-acyltransferase activator activity • phospholipid binding • apolipoprotein A-I receptor binding • enzyme binding • cholesterol transporter activity • beta-amyloid binding • phospholipid transporter activity • protein binding • chemorepellent activity • lipid transporter activity • cholesterol binding • identical protein binding • high-density lipoprotein particle binding • lipid binding
Cellular component	• cytosol • endoplasmic reticulum lumen • chylomicron • extracellular region • nucleus • extracellular vesicle • endocytic vesicle lumen • discoidal high-density lipoprotein particle • very-low-density lipoprotein particle • cell surface • secretory granule lumen • extracellular exosome • blood microparticle • endocytic vesicle • plasma membrane • spherical high-density lipoprotein particle • early endosome • high-density lipoprotein particle • cytoplasmic vesicle • extracellular space
Biological process	• positive regulation of Rho protein signal transduction • regulation of protein phosphorylation • cholesterol import • lipid transport • negative chemotaxis • positive regulation of cholesterol esterification • phospholipid efflux • phospholipid transport • negative regulation of hydrolase activity • receptor-mediated endocytosis • retinoid metabolic process • negative regulation of lipase activity • regulation of intestinal cholesterol absorption • negative regulation of cell adhesion molecule production • peripheral nervous system axon regeneration • endothelial cell proliferation • animal organ regeneration • peptidyl-methionine modification • cholesterol homeostasis • negative regulation of heterotypic cell-cell adhesion • transforming growth factor beta receptor signaling pathway • protein oxidation • negative regulation of inflammatory response • negative regulation of interleukin-1 beta secretion • phospholipid homeostasis • ERK1 and ERK2 cascade • negative regulation of cytokine secretion involved in immune response • positive regulation of fatty acid biosynthetic process • high-density lipoprotein particle clearance • lipoprotein metabolic process • G-protein coupled receptor signaling pathway • positive regulation of triglyceride catabolic process • response to nutrient • glucocorticoid metabolic process • lipid storage • protein stabilization • positive regulation of lipoprotein lipase activity • cholesterol metabolic process • response to estrogen • triglyceride catabolic process • transmembrane transport • transport • cholesterol efflux • integrin-mediated signaling pathway • phosphatidylcholine biosynthetic process • neuron projection regeneration • cellular protein metabolic process • negative regulation of very-low-density lipoprotein particle remodeling • steroid metabolic process • positive regulation of hydrolase activity • regulation of Cdc42 protein signal transduction • blood vessel endothelial cell migration • negative regulation of tumor necrosis factor-mediated signaling pathway • lipid metabolic process • cholesterol transport • platelet degranulation • adrenal gland development • high-density lipoprotein particle assembly • negative regulation of response to cytokine stimulus • high-density lipoprotein particle remodeling • positive regulation of substrate adhesion-dependent cell spreading • phospholipid metabolic process • vitamin transport • cholesterol biosynthetic process • response to drug • positive regulation of stress fiber assembly • triglyceride homeostasis • reverse cholesterol transport • lipoprotein biosynthetic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


335


11806

Ensembl


ENSG00000118137


ENSMUSG00000032083

UniProt


P02647


Q00623

RefSeq (mRNA)


NM_000039 NM_001318017 NM_001318018 NM_001318021


NM_009692

RefSeq (protein)

NP_000030 NP_001304946 NP_001304947 NP_001304950 NP_000030.1
NP_001304946.1 NP_001304947.1


NP_033822.2 NP_033822

Location (UCSC)

Chr 11: 116.84 – 116.84 Mb

Chr 9: 46.23 – 46.23 Mb

PubMed search

1AV1, 1GW3, 1GW4, 1ODP, 1ODQ, 1ODR, 2A01, 3K2S, 3R2P, 2MSC, 2MSD, 2MSE, 4V6M

NM_000039
NM_001318017
NM_001318018
NM_001318021

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