AP2B1

AP2B1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1E42, 2G30, 2IV8, 2IV9, 2JKR, 2JKT, 2VGL, 2XA7, 4UQI
Identifiers
Aliases	AP2B1, ADTB2, AP105B, AP2-BETA, CLAPB1, adaptor related protein complex 2 beta 1 subunit
External IDs	HomoloGene: 68176 GeneCards: AP2B1
Gene ontology Molecular function • clathrin adaptor activity • protein complex binding • clathrin binding • protein transporter activity • signal sequence binding • protein binding Cellular component • endocytic vesicle membrane • cytosol • clathrin-coated endocytic vesicle membrane • membrane • clathrin coat • plasma membrane • trans-Golgi network • endolysosome membrane • membrane coat • clathrin-coated pit • AP-2 adaptor complex • clathrin adaptor complex Biological process • cardiac septum development • endocytosis • ventricular septum development • antigen processing and presentation of exogenous peptide antigen via MHC class II • ephrin receptor signaling pathway • regulation of defense response to virus by virus • coronary vasculature development • aorta development • heart development • clathrin-dependent endocytosis • transport • clathrin coat assembly • protein transport • intracellular protein transport • vesicle-mediated transport • microtubule-based movement • Wnt signaling pathway, planar cell polarity pathway • receptor-mediated endocytosis • membrane organization • neurotransmitter receptor internalization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	163	n/a
Ensembl	ENSG00000006125	n/a
UniProt	P63010	n/a
RefSeq (mRNA)	NM_001030006 NM_001282	n/a
RefSeq (protein)	NP_001025177 NP_001273	n/a
Location (UCSC)	Chr 17: 35.58 – 35.73 Mb	n/a
PubMed search		n/a

1E42, 2G30, 2IV8, 2IV9, 2JKR, 2JKT, 2VGL, 2XA7, 4UQI

163

n/a

ENSG00000006125

n/a

P63010

n/a

NM_001030006
NM_001282

n/a

NP_001025177
NP_001273

n/a

AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.

The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene.

AP2B1 has been shown to interact with:

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Wikipedia