AOF2

KDM1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48, 2Z3Y, 2Z5U, 3ABT, 3ZMS, 3ZMT, 3ZMU, 3ZMV, 3ZMZ, 3ZN0, 3ZN1, 4BAY, 4CZZ, 4KUM, 4UV8, 4UV9, 4UVA, 4UVB, 4UVC, 4UXN, 5AFW, 5L3D, 5L3B, 5IT3, 5L3C, 4XBF
Identifiers
Aliases	KDM1A, AOF2, BHC110, KDM1, LSD1, CPRF, lysine demethylase 1A
External IDs	MGI: 1196256 HomoloGene: 32240 GeneCards: KDM1A
Gene location (Human) Chr. Chromosome 1 (human) Band n/a Start 23,019,448 bp End 23,083,689 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band n/a Start 136,550,540 bp End 136,602,723 bp
Gene ontology Molecular function • DNA binding • telomeric repeat-containing RNA binding • histone demethylase activity (H3-K9 specific) • demethylase activity • telomeric DNA binding • flavin adenine dinucleotide binding • p53 binding • transcription factor binding • protein binding • androgen receptor binding • ligand-dependent nuclear receptor transcription coactivator activity • histone demethylase activity (H3-K4 specific) • oxidoreductase activity • chromatin binding • histone deacetylase activity • histone demethylase activity • enzyme binding • histone demethylase activity (H3-dimethyl-K4 specific) • MRF binding • transcription regulatory region DNA binding Cellular component • DNA repair complex • nucleoplasm • protein complex • nuclear chromatin • nucleus • nuclear chromosome, telomeric region • transcription factor complex Biological process • regulation of transcription, DNA-templated • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of double-strand break repair via homologous recombination • cellular response to UV • histone H3-K4 demethylation • regulation of transcription from RNA polymerase II promoter • negative regulation of DNA binding • protein demethylation • positive regulation of sequence-specific DNA binding transcription factor activity • regulation of cellular protein localization • blood coagulation • negative regulation of protein binding • negative regulation of sequence-specific DNA binding transcription factor activity • transcription, DNA-templated • multicellular organism development • negative regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of histone ubiquitination • cellular response to gamma radiation • negative regulation of transcription, DNA-templated • oxidation-reduction process • positive regulation of transcription from RNA polymerase II promoter • alternative mRNA splicing, via spliceosome • cerebral cortex development • positive regulation of cell size • response to organic cyclic compound • guanine metabolic process • cellular response to cAMP • positive regulation of chromatin binding • histone deacetylation • positive regulation of neuron projection development • neuron maturation • response to fungicide • covalent chromatin modification • negative regulation of transcription from RNA polymerase II promoter • histone H3-K9 demethylation • muscle cell development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23028	99982
Ensembl	ENSG00000004487	ENSMUSG00000036940
UniProt	O60341	Q6ZQ88
RefSeq (mRNA)	NM_001009999 NM_015013	NM_133872 NM_001347221
RefSeq (protein)	NP_001009999 NP_055828	NP_001334150 NP_598633
Location (UCSC)	Chr 1: 23.02 – 23.08 Mb	Chr 1: 136.55 – 136.6 Mb
PubMed search

2COM, 2DW4, 2EJR, 2H94, 2HKO, 2IW5, 2L3D, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48, 2Z3Y, 2Z5U, 3ABT, 3ZMS, 3ZMT, 3ZMU, 3ZMV, 3ZMZ, 3ZN0, 3ZN1, 4BAY, 4CZZ, 4KUM, 4UV8, 4UV9, 4UVA, 4UVB, 4UVC, 4UXN, 5AFW, 5L3D, 5L3B, 5IT3, 5L3C, 4XBF

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