AOF1

KDM1B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4FWE, 4FWF, 4FWJ, 4GU0, 4GU1, 4GUR, 4GUS, 4GUT, 4GUU, 4HSU
Identifiers
Aliases	KDM1B, AOF1, C6orf193, LSD2, bA204B7.3, dJ298J15.2, lysine demethylase 1B
External IDs	HomoloGene: 131158 GeneCards: KDM1B
Gene location (Human) Chr. Chromosome 6 (human) Band n/a Start 18,155,329 bp End 18,223,853 bp
Gene ontology Molecular function • metal ion binding • DNA binding • oxidoreductase activity • flavin adenine dinucleotide binding • histone demethylase activity • protein binding • zinc ion binding • histone demethylase activity (H3-dimethyl-K4 specific) • histone demethylase activity (H3-monomethyl-K4 specific) • histone binding • FAD binding Cellular component • nucleus • nucleoplasm • nucleosome Biological process • multicellular organism development • regulation of transcription, DNA-templated • regulation of gene expression by genetic imprinting • regulation of DNA methylation • transcription, DNA-templated • DNA methylation involved in gamete generation • oxidation-reduction process • covalent chromatin modification • protein deubiquitination • histone H3-K4 demethylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221656	n/a
Ensembl	ENSG00000165097	n/a
UniProt	Q8NB78	n/a
RefSeq (mRNA)	NM_153042	n/a
RefSeq (protein)	NP_694587	n/a
Location (UCSC)	Chr 6: 18.16 – 18.22 Mb	n/a
PubMed search		n/a

4FWE, 4FWF, 4FWJ, 4GU0, 4GU1, 4GUR, 4GUS, 4GUT, 4GUU, 4HSU

221656

n/a

ENSG00000165097

n/a

Q8NB78

n/a

NM_153042

n/a

NP_694587

n/a

Lysine (K)-specific demethylase 1B is a protein that in humans is encoded by the KDM1B gene.

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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