ANAPC2

ANAPC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UI9, 4YII, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC2, APC2, anaphase promoting complex subunit 2
External IDs	MGI: 2139135 HomoloGene: 8359 GeneCards: ANAPC2
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.3 Start 137,174,784 bp End 137,188,549 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 25,272,478 bp End 25,285,915 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • ubiquitin protein ligase activity • ubiquitin protein ligase binding • protein binding Cellular component • cytosol • nucleoplasm • anaphase-promoting complex • nucleus Biological process • cell differentiation • ubiquitin-dependent protein catabolic process • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • nervous system development • positive regulation of synaptic plasticity • protein K11-linked ubiquitination • cell division • positive regulation of synapse maturation • positive regulation of dendrite morphogenesis • protein ubiquitination • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • cell cycle • anaphase-promoting complex-dependent catabolic process • positive regulation of axon extension • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • proteasome-mediated ubiquitin-dependent protein catabolic process • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29882	99152
Ensembl	ENSG00000176248	ENSMUSG00000026965
UniProt	Q9UJX6	Q8BZQ7
RefSeq (mRNA)	NM_013366	NM_175300
RefSeq (protein)	NP_037498	NP_780509
Location (UCSC)	Chr 9: 137.17 – 137.19 Mb	Chr 9: 25.27 – 25.29 Mb
PubMed search

4UI9, 4YII, 5A31, 5G05, 5G04

29882

99152

ENSG00000176248

ENSMUSG00000026965

Q9UJX6

Q8BZQ7

NM_013366

NM_175300

NP_037498

NP_780509

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation.

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Wikipedia