ALYREF

ALYREF
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3ULH
Identifiers
Aliases	ALYREF, ALY, ALY/REF, BEF, REF, THOC4, Aly/REF export factor
External IDs	HomoloGene: 134554 GeneCards: ALYREF
Gene ontology Molecular function • protein binding • nucleic acid binding • RNA binding Cellular component • cytoplasm • cytosol • nuclear speck • catalytic step 2 spliceosome • membrane • transcription export complex • exon-exon junction complex • spliceosomal complex • extracellular exosome • nuclear chromosome, telomeric region • nucleus • nucleoplasm Biological process • regulation of DNA recombination • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA transport • mRNA processing • viral mRNA export from host cell nucleus • mRNA export from nucleus • positive regulation of DNA-templated transcription, elongation • osteoblast differentiation • replication fork processing • viral process • mRNA 3'-end processing • RNA splicing • RNA export from nucleus • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10189	n/a
Ensembl	ENSG00000183684	n/a
UniProt	Q86V81	n/a
RefSeq (mRNA)	NM_005782	n/a
RefSeq (protein)	NP_005773	n/a
Location (UCSC)	Chr 17: 81.89 – 81.89 Mb	n/a
PubMed search		n/a

3ULH

10189

n/a

ENSG00000183684

n/a

Q86V81

n/a

NM_005782

n/a

NP_005773

n/a

Aly/REF export factor, also known as THO complex subunit 4 is a protein that in humans is encoded by the ALYREF gene.

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.

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