ALK1 inhibitor

ACVRL1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2LCR, 3MY0, 4FAO

Identifiers

Aliases

ACVRL1, ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I, activin A receptor like type 1

External IDs

OMIM: 601284 MGI: 1338946 HomoloGene: 20058 GeneCards: ACVRL1

Gene location (Human)

Chr.	Chromosome 12 (human)

Band	n/a	Start	51,906,908 bp
Band	n/a	End	51,923,361 bp

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)

Band	n/a	Start	101,128,522 bp
Band	n/a	End	101,145,336 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • activin receptor activity, type I • nucleotide binding • protein kinase activity • signal transducer, downstream of receptor, with serine/threonine kinase activity • activin binding • transforming growth factor beta-activated receptor activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • transmembrane receptor protein serine/threonine kinase activity • transforming growth factor beta receptor activity, type I • protein binding • BMP receptor activity • SMAD binding • ATP binding • protein kinase binding • transforming growth factor beta binding
Cellular component	• integral component of membrane • membrane • integral component of plasma membrane • cell surface • neuronal cell body • dendrite • plasma
Biological process	• cellular response to transforming growth factor beta stimulus • negative regulation of cell adhesion • regulation of transcription, DNA-templated • positive regulation of endothelial cell differentiation • positive regulation of endothelial cell proliferation • blood vessel morphogenesis • negative regulation of blood vessel endothelial cell migration • protein heterooligomerization • signal transduction by protein phosphorylation • lymphangiogenesis • regulation of DNA replication • phosphorylation • endothelial tube morphogenesis • retina vasculature development in camera-type eye • wound healing, spreading of epidermal cells • lymphatic endothelial cell differentiation • positive regulation of pathway-restricted SMAD protein phosphorylation • cellular response to BMP stimulus • negative regulation of endothelial cell differentiation • in utero embryonic development • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • blood circulation • positive regulation of angiogenesis • venous blood vessel development • negative regulation of endothelial cell migration • negative regulation of endothelial cell proliferation • regulation of blood vessel endothelial cell migration • regulation of blood pressure • positive regulation of transcription, DNA-templated • protein phosphorylation • blood vessel remodeling • negative regulation of cell migration • transmembrane receptor protein serine/threonine kinase signaling pathway • negative regulation of cell growth • positive regulation of chondrocyte differentiation • angiogenesis • artery development • regulation of endothelial cell proliferation • positive regulation of BMP signaling pathway • transforming growth factor beta receptor signaling pathway • negative regulation of focal adhesion assembly • negative regulation of DNA biosynthetic process • signal transduction • negative regulation of cell proliferation • blood vessel maturation • activin receptor signaling pathway • response to hypoxia • endocardial cushion to mesenchymal transition • endocardial cushion morphogenesis • negative regulation of gene expression • dorsal aorta morphogenesis • positive regulation of transcription from RNA polymerase II promoter • BMP signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


94


11482

Ensembl


ENSG00000139567


ENSMUSG00000000530

UniProt


P37023


Q61288

RefSeq (mRNA)


NM_000020 NM_001077401


NM_001277255 NM_001277257 NM_001277258 NM_001277259 NM_009612

RefSeq (protein)


NP_000011 NP_001070869


NP_001264184 NP_001264186 NP_001264187 NP_001264188 NP_033742

Location (UCSC)

Chr 12: 51.91 – 51.92 Mb

Chr 12: 101.13 – 101.15 Mb

PubMed search

2LCR, 3MY0, 4FAO

NM_000020
NM_001077401

NM_001277255
NM_001277257
NM_001277258
NM_001277259
NM_009612

NP_000011
NP_001070869

NP_001264184
NP_001264186
NP_001264187
NP_001264188
NP_033742

...
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