ALDH1A1

ALDH1A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WB9, 4WJ9, 4WP7, 4WPN, 4X4L, 5AC2
Identifiers
Aliases	ALDH1A1, ALDC, ALDH-E1, ALDH1, ALDH11, HEL-9, HEL-S-53e, HEL12, PUMB1, RALDH1, aldehyde dehydrogenase 1 family member A1
External IDs	MGI: 1353450 HomoloGene: 110441 GeneCards: ALDH1A1
Gene ontology Molecular function • oxidoreductase activity • benzaldehyde dehydrogenase (NAD+) activity • androgen binding • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor • aldehyde dehydrogenase (NAD) activity • GTPase activator activity • nucleotide binding • retinal dehydrogenase activity Cellular component • cytoplasm • extracellular exosome • cytosol Biological process • retinol metabolic process • cellular aldehyde metabolic process • metabolic process • ethanol oxidation • positive regulation of GTPase activity • fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate • retinoid metabolic process • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	216	11668
Ensembl	ENSG00000165092	ENSMUSG00000053279
UniProt	P00352 Q5SYQ7	P24549
RefSeq (mRNA)	NM_000689	NM_013467
RefSeq (protein)	NP_000680	NP_038495.2 NP_038495
Location (UCSC)	Chr 9: 72.9 – 73.08 Mb	Chr 19: 20.6 – 20.64 Mb
PubMed search

4WB9, 4WJ9, 4WP7, 4WPN, 4X4L, 5AC2

216

11668

ENSG00000165092

ENSMUSG00000053279

P00352
Q5SYQ7

P24549

NM_000689

NM_013467

NP_000680

NP_038495.2
NP_038495

Aldehyde dehydrogenase 1 family, member A1, also known as ALDH1A1 or retinaldehyde dehydrogenase 1 (RALDH1), is an enzyme that in humans is encoded by the ALDH1A1 gene.

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and , can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes the main cytosolic isoform, which has a lower affinity for aldehydes than the mitochondrial enzyme.

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Wikipedia