AKT3

AKT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X18
Identifiers
Aliases	AKT3, MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2, AKT serine/threonine kinase 3
External IDs	MGI: 1345147 HomoloGene: 55904 GeneCards: AKT3
Genetically Related Diseases
post-traumatic stress disorder
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding • kinase activity Cellular component • intracellular • membrane • nucleus • cytoplasm Biological process • protein phosphorylation • intracellular signal transduction • peptidyl-serine phosphorylation • mitochondrial genome maintenance • signal transduction • phosphorylation • positive regulation of TOR signaling • positive regulation of cell size • brain morphogenesis • homeostasis of number of cells within a tissue Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10000	23797
Ensembl	n/a	ENSMUSG00000019699
UniProt	Q9Y243	Q9WUA6
RefSeq (mRNA)	NM_001206729 NM_005465 NM_181690	NM_011785
RefSeq (protein)	NP_001193658 NP_005456 NP_859029	NP_035915.3 NP_035915
Location (UCSC)	Chr 1: 243.49 – 243.85 Mb	Chr 1: 177.02 – 177.26 Mb
PubMed search

2X18

10000

23797

n/a

ENSMUSG00000019699

Q9Y243

Q9WUA6

NM_001206729
NM_005465
NM_181690

NM_011785

NP_001193658
NP_005456
NP_859029

NP_035915.3
NP_035915

RAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene.

The protein encoded by this gene is a member of the AKT subfamily of serine/threonine protein kinases. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. Mice lacking Akt3 have a normal glucose metabolism (no diabetes), have approximately normal body weight, but have a 25% reduction in brain mass. Incidentally, Akt3 is highly expressed in the brain.

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Wikipedia