AKR1C3

AKR1C3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2FGB, 3R43, 3R58, 3R6I, 3R7M, 3R8G, 3R8H, 3R94, 3UFY, 3UG8, 3UGR, 3UWE, 4DBS, 4DBU, 4DBW, 4DZ5, 4FA3, 4FAL, 4FAM, 4H7C, 4HMN, 4WDT, 4WDU, 4WDW, 4WDX, 4WRH, 4XVD, 4XVE, 4ZFC, 4YVX, 4YVV
Identifiers
Aliases	AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS, aldo-keto reductase family 1, member C3
External IDs	MGI: 2145420 HomoloGene: 128661 GeneCards: AKR1C3
EC number	1.3.1.20
Targeted by Drug
tolfenamic acid
Gene ontology Molecular function • delta4-3-oxosteroid 5beta-reductase activity • prostaglandin-F synthase activity • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity • alditol:NADP+ 1-oxidoreductase activity • retinal dehydrogenase activity • geranylgeranyl reductase activity • indanol dehydrogenase activity • aldo-keto reductase (NADP) activity • dihydrotestosterone 17-beta-dehydrogenase activity • phenanthrene 9,10-monooxygenase activity • ketoreductase activity • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor • testosterone dehydrogenase (NAD+) activity • retinol dehydrogenase activity • testosterone 17-beta-dehydrogenase (NADP+) activity • oxidoreductase activity • androsterone dehydrogenase activity • 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity • ketosteroid monooxygenase activity • NADP-retinol dehydrogenase activity • prostaglandin D2 11-ketoreductase activity • prostaglandin H2 endoperoxidase reductase activity Cellular component • cytoplasm • cytosol • intracellular • extracellular exosome • nucleus Biological process • cellular response to calcium ion • negative regulation of retinoic acid biosynthetic process • prostaglandin metabolic process • G-protein coupled receptor signaling pathway • cellular response to jasmonic acid stimulus • steroid metabolic process • positive regulation of protein kinase B signaling • male gonad development • positive regulation of cell death • daunorubicin metabolic process • doxorubicin metabolic process • response to nutrient • regulation of retinoic acid receptor signaling pathway • progesterone metabolic process • cellular response to starvation • regulation of testosterone biosynthetic process • protein import into nucleus, translocation • cellular response to cadmium ion • cellular response to corticosteroid stimulus • cyclooxygenase pathway • keratinocyte differentiation • retinal metabolic process • retinoid metabolic process • cellular response to reactive oxygen species • farnesol catabolic process • positive regulation of endothelial cell apoptotic process • positive regulation of reactive oxygen species metabolic process • cellular response to prostaglandin D stimulus • positive regulation of cell proliferation • oxidation-reduction process • multicellular organismal macromolecule metabolic process • renal absorption • testosterone biosynthetic process • cellular response to prostaglandin stimulus • retinol metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8644	105349
Ensembl	n/a	ENSMUSG00000021214
UniProt	P42330	Q8K023
RefSeq (mRNA)	NM_003739 NM_001253908 NM_001253909	NM_134066 NM_001346535
RefSeq (protein)	NP_001240837 NP_001240838 NP_003730	NP_598827.1 NP_001333464 NP_598827
Location (UCSC)	Chr 10: 5.04 – 5.11 Mb	Chr 13: 4.13 – 4.15 Mb
PubMed search

1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2FGB, 3R43, 3R58, 3R6I, 3R7M, 3R8G, 3R8H, 3R94, 3UFY, 3UG8, 3UGR, 3UWE, 4DBS, 4DBU, 4DBW, 4DZ5, 4FA3, 4FAL, 4FAM, 4H7C, 4HMN, 4WDT, 4WDU, 4WDW, 4WDX, 4WRH, 4XVD, 4XVE, 4ZFC, 4YVX, 4YVV

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