AKR1C1

AKR1C1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MRQ, 3C3U, 3GUG, 3NTY, 4YVP
Identifiers
Aliases	AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB, aldo-keto reductase family 1, member C1, aldo-keto reductase family 1 member C1
External IDs	MGI: 1924587 HomoloGene: 134114 GeneCards: AKR1C1
EC number	1.1.1.112
Gene ontology Molecular function • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity • alditol:NADP+ 1-oxidoreductase activity • indanol dehydrogenase activity • aldo-keto reductase (NADP) activity • 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity • androsterone dehydrogenase (B-specific) activity • phenanthrene 9,10-monooxygenase activity • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor • bile acid binding • protein binding • carboxylic acid binding • oxidoreductase activity • ketosteroid monooxygenase activity Cellular component • cytoplasm • cytosol • extracellular exosome Biological process • cellular response to jasmonic acid stimulus • epithelial cell differentiation • daunorubicin metabolic process • doxorubicin metabolic process • progesterone metabolic process • bile acid metabolic process • digestion • retinal metabolic process • retinoid metabolic process • response to organophosphorus • bile acid and bile salt transport • intestinal cholesterol absorption • xenobiotic metabolic process • cholesterol homeostasis • protein homooligomerization • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1645	77337
Ensembl	ENSG00000187134	ENSMUSG00000021207
UniProt	Q04828	Q91WR5
RefSeq (mRNA)	NM_001353	NM_029901
RefSeq (protein)	NP_001344	NP_084177.2 NP_084177
Location (UCSC)	Chr 10: 4.96 – 5.11 Mb	Chr 13: 4.57 – 4.59 Mb
PubMed search

1MRQ, 3C3U, 3GUG, 3NTY, 4YVP

1645

77337

ENSG00000187134

ENSMUSG00000021207

Q04828

Q91WR5

NM_001353

NM_029901

NP_001344

NP_084177.2
NP_084177

Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members, and is clustered with those three genes at chromosome 10p15-p14.

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Wikipedia