AIF1

AIF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D58, 2G2B
Identifiers
Aliases	AIF1, AIF-1, IBA1, IRT-1, IRT1, allograft inflammatory factor 1
External IDs	MGI: 1343098 HomoloGene: 1226 GeneCards: AIF1
Gene ontology Molecular function • calcium ion binding • metal ion binding • actin filament binding • actin binding Cellular component • cytoplasm • cytosol • perikaryon • cell projection • membrane • ruffle • plasma membrane • ruffle membrane • actin filament • perinuclear region of cytoplasm • phagocytic cup • cytoskeleton • nucleus • lamellipodium Biological process • cellular response to extracellular stimulus • positive regulation of smooth muscle cell chemotaxis • response to cytokine • positive regulation of protein phosphorylation • negative regulation of smooth muscle cell proliferation • positive regulation of cell migration • positive regulation of muscle hyperplasia • positive regulation of nitric oxide biosynthetic process • positive regulation of monocyte chemotaxis • negative regulation of apoptotic process • response to glucocorticoid • response to electrical stimulus • negative regulation of gene expression • cellular response to hydroperoxide • actin filament bundle assembly • microglial cell activation • positive regulation of G1/S transition of mitotic cell cycle • actin filament polymerization • negative regulation of smooth muscle cell chemotaxis • cellular response to hormone stimulus • phagocytosis, engulfment • response to axon injury • positive regulation of T cell proliferation • cellular response to interferon-gamma • cellular response to morphine • Rac protein signal transduction • inflammatory response • ruffle assembly • positive regulation of T cell migration • positive regulation of smooth muscle cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	199	11629
Ensembl	n/a	ENSMUSG00000024397
UniProt	P55008 Q4V347	O70200
RefSeq (mRNA)	NM_001623 NM_004847 NM_032955 NM_001318970	NM_019467
RefSeq (protein)	NP_001305899 NP_001614 NP_116573 NP_001614.3	NP_062340.1 NP_062340
Location (UCSC)	Chr 6: 31.62 – 31.62 Mb	Chr 17: 35.17 – 35.18 Mb
PubMed search

2D58, 2G2B

199

11629

n/a

ENSMUSG00000024397

P55008
Q4V347

O70200

NM_001623
NM_004847
NM_032955
NM_001318970

NM_019467

NP_001305899
NP_001614
NP_116573
NP_001614.3

NP_062340.1
NP_062340

Allograft inflammatory factor 1 (AIF-1) also known as ionized calcium-binding adapter molecule 1 (IBA1) is a protein that in humans is encoded by the AIF1 gene.

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Wikipedia