ADH6

Identifiers

ADH6, ADH-5, alcohol dehydrogenase 6 (class V)

External IDs

Gene ontology
Molecular function	• oxidoreductase activity • zinc ion binding • alcohol dehydrogenase (NAD) activity • metal ion binding • alcohol dehydrogenase activity, zinc-dependent
Cellular component	• cytoplasm • cytosol • extracellular exosome
Biological process	• response to ethanol • oxidation-reduction process • ethanol oxidation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


130


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Ensembl


ENSG00000172955


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UniProt


P28332


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RefSeq (mRNA)


NM_000672 NM_001102470


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RefSeq (protein)


NP_000663 NP_001095940


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Location (UCSC)

Chr 4: 99.2 – 99.22 Mb

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PubMed search

n/a

130

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ENSG00000172955

n/a

P28332

n/a

NM_000672
NM_001102470

n/a

NP_000663
NP_001095940

n/a

Alcohol dehydrogenase 6 is an enzyme that in humans is encoded by the ADH6 gene.

This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. The deduced amino acid sequence of the open reading frame of this gene shows about 60% positional identity with other known alcohol dehydrogenases. This gene may have a distinct physiologic function.

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