ADH4

ADH4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3COS
Identifiers
Aliases	ADH4, ADH-2, HEL-S-4, alcohol dehydrogenase 4 (class II), pi polypeptide
External IDs	MGI: 1349472 HomoloGene: 20162 GeneCards: ADH4
Gene ontology Molecular function • benzaldehyde dehydrogenase activity • all-trans retinal binding • NADPH:quinone reductase activity • alditol:NADP+ 1-oxidoreductase activity • NAD binding • zinc ion binding • metal ion binding • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor • retinol binding • ethanol binding • oxidoreductase activity • alcohol dehydrogenase (NAD) activity • alcohol dehydrogenase activity, zinc-dependent • retinol dehydrogenase activity Cellular component • cytoplasm • nucleus • cytosol Biological process • quinone metabolic process • retinol metabolic process • retinoid metabolic process • cellular aldehyde metabolic process • alcohol catabolic process • ethanol metabolic process • alcohol metabolic process • oxidation-reduction process • ethanol oxidation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	127	26876
Ensembl	ENSG00000198099	ENSMUSG00000037797
UniProt	P08319	Q9QYY9
RefSeq (mRNA)	NM_000670 NM_001306171 NM_001306172	NM_011996
RefSeq (protein)	NP_000661 NP_001293100 NP_001293101	NP_036126.2 NP_036126
Location (UCSC)	Chr 4: 99.12 – 99.16 Mb	Chr 3: 138.42 – 138.43 Mb
PubMed search

3COS

127

26876

ENSG00000198099

ENSMUSG00000037797

P08319

Q9QYY9

NM_000670
NM_001306171
NM_001306172

NM_011996

NP_000661
NP_001293100
NP_001293101

NP_036126.2
NP_036126

Alcohol dehydrogenase 4 is an enzyme that in humans is encoded by the ADH4 gene.

This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.

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