ADAMTS1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2JIH, 2V4B, 3Q2G, 3Q2H

Identifiers

Aliases

ADAMTS1, C3-C5, METH1, ADAM metallopeptidase with thrombospondin type 1 motif 1

External IDs

MGI: 109249 HomoloGene: 21381 GeneCards: ADAMTS1

Gene ontology
Molecular function	• heparin binding • zinc ion binding • metal ion binding • peptidase activity • metalloendopeptidase activity • hydrolase activity • metallopeptidase activity
Cellular component	• proteinaceous extracellular matrix • extracellular region • basement membrane • cytoplasmic vesicle • cytosol
Biological process	• ovulation from ovarian follicle • heart trabecula formation • kidney development • proteolysis • integrin-mediated signaling pathway • negative regulation of cell proliferation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9510


11504

Ensembl


ENSG00000154734


ENSMUSG00000022893

UniProt


Q9UHI8


P97857

RefSeq (mRNA)


NM_006988


NM_009621

RefSeq (protein)


NP_008919


NP_033751

Location (UCSC)

Chr 21: 26.84 – 26.85 Mb

Chr 16: 85.79 – 85.8 Mb

PubMed search

2JIH, 2V4B, 3Q2G, 3Q2H

A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.

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