ADAM17

ADAM17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BKC, 1ZXC, 2A8H, 2DDF, 2FV5, 2FV9, 2I47, 2M2F, 2OI0, 3B92, 3CKI, 3E8R, 3EDZ, 3EWJ, 3G42, 3KMC, 3KME, 3L0T, 3L0V, 3LE9, 3LEA, 3LGP, 3O64
Identifiers
Aliases	ADAM17, ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE, ADAM metallopeptidase domain 17
External IDs	OMIM: 603639 MGI: 1096335 HomoloGene: 2395 GeneCards: ADAM17
Gene ontology Molecular function • PDZ domain binding • interleukin-6 receptor binding • SH3 domain binding • metal ion binding • Notch binding • integrin binding • peptidase activity • protein binding • metalloendopeptidase activity • hydrolase activity • metallopeptidase activity Cellular component • cytoplasm • integral component of membrane • membrane • cell-cell junction • focal adhesion • plasma membrane • integral component of plasma membrane • ruffle membrane • cell surface • apical plasma membrane • actin cytoskeleton • membrane raft • cytosol Biological process • Notch signaling pathway • positive regulation of transforming growth factor beta receptor signaling pathway • positive regulation of epidermal growth factor-activated receptor activity • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle • positive regulation of protein phosphorylation • response to hypoxia • T cell differentiation in thymus • cell motility • positive regulation of cell migration • epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway • response to high density lipoprotein particle • wound healing, spreading of epidermal cells • germinal center formation • tumor necrosis factor-mediated signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • spleen development • proteolysis • positive regulation of leukocyte chemotaxis • positive regulation of cell growth • response to lipopolysaccharide • cell adhesion • cell adhesion mediated by integrin • membrane protein ectodomain proteolysis • membrane protein intracellular domain proteolysis • regulation of mast cell apoptotic process • positive regulation of T cell chemotaxis • PMA-inducible membrane protein ectodomain proteolysis • positive regulation of cell proliferation • Notch receptor processing • positive regulation of chemokine production • positive regulation of cellular component movement • neutrophil mediated immunity • B cell differentiation • response to drug • defense response to Gram-positive bacterium • epidermal growth factor receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6868	11491
Ensembl	ENSG00000151694	ENSMUSG00000052593
UniProt	P78536	Q9Z0F8
RefSeq (mRNA)	NM_003183	NM_001277266 NM_009615 NM_001291871
RefSeq (protein)	NP_003174	NP_001264195 NP_001278800 NP_033745
Location (UCSC)	Chr 2: 9.49 – 9.56 Mb	Chr 12: 21.32 – 21.37 Mb
PubMed search

1BKC, 1ZXC, 2A8H, 2DDF, 2FV5, 2FV9, 2I47, 2M2F, 2OI0, 3B92, 3CKI, 3E8R, 3EDZ, 3EWJ, 3G42, 3KMC, 3KME, 3L0T, 3L0V, 3LE9, 3LEA, 3LGP, 3O64

6868

11491

ENSG00000151694

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