ADAM10

ADAM10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M1I
Identifiers
Aliases	ADAM10, AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz, CDw156, ADAM metallopeptidase domain 10
External IDs	MGI: 109548 HomoloGene: 865 GeneCards: ADAM10
Gene ontology Molecular function • protein homodimerization activity • SH3 domain binding • endopeptidase activity • metal ion binding • integrin binding • peptidase activity • protein binding • receptor binding • hydrolase activity • protein kinase binding • metallopeptidase activity • metalloendopeptidase activity Cellular component • cytoplasm • integral component of membrane • membrane • postsynaptic density • focal adhesion • plasma membrane • perinuclear endoplasmic reticulum • Golgi-associated vesicle • tetraspanin-enriched microdomain • extracellular exosome • nucleus • cell surface • Golgi membrane • extracellular space • Golgi apparatus • specific granule membrane • tertiary granule membrane Biological process • Notch signaling pathway • positive regulation of cell migration • ephrin receptor signaling pathway • cell-cell signaling • constitutive protein ectodomain proteolysis • protein processing • extracellular matrix disassembly • in utero embryonic development • proteolysis • monocyte activation • response to tumor necrosis factor • protein phosphorylation • positive regulation of cell growth • positive regulation of T cell chemotaxis • PMA-inducible membrane protein ectodomain proteolysis • positive regulation of cell proliferation • Notch receptor processing • integrin-mediated signaling pathway • membrane protein ectodomain proteolysis • negative regulation of cell adhesion • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	102	11487
Ensembl	ENSG00000137845	ENSMUSG00000054693
UniProt	O14672	O35598
RefSeq (mRNA)	NM_001110 NM_001320570	NM_007399
RefSeq (protein)	NP_001101 NP_001307499 NP_001101.1	NP_031425.2 NP_031425
Location (UCSC)	Chr 15: 58.59 – 58.75 Mb	Chr 9: 70.68 – 70.78 Mb
PubMed search

ADAM10 endopeptidase
Identifiers
EC number	3.4.24.81
CAS number	193099-09-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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PubMed	articles
NCBI	proteins

1M1I

102

11487

ENSG00000137845

ENSMUSG00000054693

O14672

O35598

NM_001110
NM_001320570

NM_007399

NP_001101
NP_001307499
NP_001101.1

NP_031425.2
NP_031425

A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ADAM10 gene.

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. Sheddase, a generic name for the ADAM metallopeptidase, functions primarily to cleave membrane proteins at the cellular surface. Once cleaved, the sheddases release soluble ectodomains with an altered location and function.

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