ACTA2

ACTA2
Identifiers
Aliases	ACTA2, AAT6, ACTSA, MYMY5, actin, alpha 2, smooth muscle, aorta
External IDs	MGI: 87909 HomoloGene: 133938 GeneCards: ACTA2
Gene ontology Molecular function • ATP binding • nucleotide binding • protein kinase binding Cellular component • cytosol • cytoplasm • actin cytoskeleton • smooth muscle contractile fiber • cell body • lamellipodium • protein complex • filopodium • cytoskeleton • extracellular exosome • extracellular space Biological process • muscle contraction • regulation of blood pressure • vascular smooth muscle contraction • mesenchyme migration • positive regulation of gene expression • glomerular mesangial cell development • response to virus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59	11475
Ensembl	ENSG00000107796	ENSMUSG00000035783
UniProt	P62736	P62737
RefSeq (mRNA)	NM_001141945 NM_001613 NM_001320855	NM_007392
RefSeq (protein)	NP_001135417 NP_001307784 NP_001604	NP_031418.1 NP_031418
Location (UCSC)	Chr 10: 88.94 – 88.99 Mb	Chr 19: 34.24 – 34.26 Mb
PubMed search

59

11475

ENSG00000107796

ENSMUSG00000035783

P62736

P62737

NM_001141945
NM_001613
NM_001320855

NM_007392

NP_001135417
NP_001307784
NP_001604

NP_031418.1
NP_031418

Alpha-actin-2 also known as actin, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA) is a protein that in humans is encoded by the ACTA2 gene located on 10q22-q24.

Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.

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