ACTA1

ACTA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T44
Identifiers
Aliases	ACTA1, ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3, Actin, alpha 1, SHPM, actin, alpha 1, skeletal muscle
External IDs	MGI: 87902 HomoloGene: 121702 GeneCards: ACTA1
Gene ontology Molecular function • nucleotide binding • myosin binding • ADP binding • structural constituent of cytoskeleton • protein binding • ATP binding Cellular component • cytoplasm • cell body • cytosol • blood microparticle • filopodium • sarcomere • striated muscle thin filament • stress fiber • • actin filament • actin cytoskeleton • extracellular exosome • cytoskeleton • lamellipodium Biological process • muscle contraction • response to steroid hormone • skeletal muscle fiber adaptation • response to mechanical stimulus • skeletal muscle thin filament assembly • response to lithium ion • cell growth • positive regulation of gene expression • muscle filament sliding • mesenchyme migration • response to extracellular stimulus • skeletal muscle fiber development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	58	11459
Ensembl	ENSG00000143632	ENSMUSG00000031972
UniProt	P68133	P68134
RefSeq (mRNA)	NM_001100	NM_001272041 NM_009606
RefSeq (protein)	NP_001091	NP_001258970.1 NP_033736.1 NP_001258970 NP_033736
Location (UCSC)	Chr 1: 229.43 – 229.43 Mb	Chr 8: 123.89 – 123.89 Mb
PubMed search

1T44

58

11459

ENSG00000143632

ENSMUSG00000031972

P68133

P68134

NM_001100

NM_001272041
NM_009606

NP_001091

NP_001258970.1
NP_033736.1
NP_001258970
NP_033736

Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene.

Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.

Skeletal alpha actin expression is induced by stimuli and conditions known to cause muscle formation. Such conditions result in fusion of committed cells (satellite cells) into myotubes, to form muscle fibers. Skeletal actin itself, when expressed, causes expression of several other "myogenic genes", which are essential to muscle formation. One key transcription factor that activates skeletal actin gene expression is Serum Response Factor ("SRF"), a protein that binds to specific sites on the promoter DNA of the actin gene. SRF may bring a number of other proteins to the promoter of skeletal actin, such as andogen receptor, and thereby contribute to induction of skeletal actin gene expression by androgenic (often termed "anabolic") steroids.

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Wikipedia