ACOT11

ACOT11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FO5
Identifiers
Aliases	ACOT11, BFIT, STARD14, THEA, THEM1, acyl-CoA thioesterase 11
External IDs	MGI: 1913736 HomoloGene: 11977 GeneCards: ACOT11
Gene ontology Molecular function • hydrolase activity • lipid binding • acyl-CoA hydrolase activity • carboxylic ester hydrolase activity Cellular component • extracellular exosome • cytoplasm • cytosol Biological process • intracellular signal transduction • response to temperature stimulus • response to cold • fatty acid metabolic process • acyl-CoA metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26027	329910
Ensembl	ENSG00000162390	ENSMUSG00000034853
UniProt	Q8WXI4	Q8VHQ9
RefSeq (mRNA)	NM_147161 NM_015547	NM_025590 NM_001347159
RefSeq (protein)	NP_056362 NP_671517	NP_001334088 NP_079866
Location (UCSC)	Chr 1: 54.54 – 54.64 Mb	Chr 4: 106.74 – 106.8 Mb
PubMed search

3FO5

26027

329910

ENSG00000162390

ENSMUSG00000034853

Q8WXI4

Q8VHQ9

NM_147161
NM_015547

NM_025590
NM_001347159

NP_056362
NP_671517

NP_001334088
NP_079866

Acyl-coenzyme A thioesterase 11 also known as StAR-related lipid transfer protein 14 (STARD14) is an enzyme that in humans is encoded by the ACOT11 gene. This gene encodes a protein with acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates which relies on its StAR-related lipid transfer domain. Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth. Expression of the mouse protein has been associated with obesity, with higher expression found in obesity-resistant mice compared with obesity-prone mice. Alternative splicing results in two transcript variants encoding different isoforms.

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