ACOT1

Identifiers

ACOT1, ACH2, CTE-1, LACH2, acyl-CoA thioesterase 1

External IDs

MGI: 2159619 HomoloGene: 134585 GeneCards: ACOT1

Gene location (Human)

Chr.	Chromosome 14 (human)

Band	14q24.3	Start	73,537,114 bp
Band	14q24.3	End	73,543,794 bp

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)

Band	12\|12 D1	Start	84,052,144 bp
Band	12\|12 D1	End	84,060,402 bp

Gene ontology
Molecular function	• palmitoyl-CoA hydrolase activity • carboxylic ester hydrolase activity • hydrolase activity • thiolester hydrolase activity • acyl-CoA hydrolase activity • myristoyl-CoA hydrolase activity
Cellular component	• cytoplasm • cytosol
Biological process	• very long-chain fatty acid metabolic process • long-chain fatty acid metabolic process • acyl-CoA metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


641371


171281

Ensembl


ENSG00000184227


ENSMUSG00000021228

UniProt


Q86TX2


Q9QYR7

RefSeq (mRNA)


NM_001037161


NM_134246 NM_001346701

RefSeq (protein)


NP_001032238


NP_001333630 NP_599007

Location (UCSC)

Chr 14: 73.54 – 73.54 Mb

Chr 14: 84.05 – 84.06 Mb

PubMed search

NM_134246
NM_001346701

NP_001032238

NP_001333630
NP_599007

Acyl-CoA thioesterase 1 is a protein that in humans is encoded by the ACOT1 gene.

The ACOT1 gene is located on the 14th chromosome, with its specific localization being 14q24.3. It contains 7 exons.

The protein encoded by this gene contains 410 amino acids, and forms a homodimer with another chain. The protein contains a StAR-related transfer domain, which is a domain responsible for binding to lipids. There are 4 known ligands that bind to this homodimer: polyethylene glycol, chlorine, glycerol, and a form of TCEP.

The protein encoded by the ACOT1 gene is part of a family of Acyl-CoA thioesterases, which catalyze the hydrolysis of various Coenzyme A esters of various molecules to the free acid plus CoA. These enzymes have also been referred to in the literature as acyl-CoA hydrolases, acyl-CoA thioester hydrolases, and palmitoyl-CoA hydrolases. The reaction carried out by these enzymes is as follows:

...
Wikipedia