ABCG2

ABCG2
Identifiers
Aliases	ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1, ATP binding cassette subfamily G member 2 (Junior blood group)
External IDs	MGI: 1347061 HomoloGene: 55852 GeneCards: ABCG2
Genetically Related Diseases
gout
Targeted by Drug
cyclosporine
Gene ontology Molecular function • nucleotide binding • xenobiotic-transporting ATPase activity • heme transporter activity • protein homodimerization activity • transporter activity • ATPase activity • protein binding • ATP binding • ATPase activity, coupled to transmembrane movement of substances Cellular component • integral component of membrane • mitochondrial membrane • membrane • plasma membrane • mitochondrion • nucleus Biological process • urate metabolic process • transport • response to drug • cellular iron ion homeostasis • heme transport • drug transmembrane transport • xenobiotic transport • transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9429	26357
Ensembl	ENSG00000118777	ENSMUSG00000029802
UniProt	Q9UNQ0	Q7TMS5
RefSeq (mRNA)	NM_001257386 NM_004827	NM_011920
RefSeq (protein)	NP_001244315 NP_004818	NP_036050.1
Location (UCSC)	Chr 4: 88.09 – 88.23 Mb	Chr 6: 58.58 – 58.7 Mb
PubMed search

9429

26357

ENSG00000118777

ENSMUSG00000029802

Q9UNQ0

Q7TMS5

NM_001257386
NM_004827

NM_011920

NP_001244315
NP_004818

NP_036050.1

ATP-binding cassette sub-family G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338).

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as the Breast Cancer Resistance Protein, this protein functions as a xenobiotic transporter which may play a role in multi-drug resistance to chemotherapeutic agents including mitoxantrone and camptothecin analogues. Early observations of significant ABCG2-mediated resistance to anthracyclines were subsequently attributed mutations encountered in vitro but not in nature or the clinic. Significant expression of this protein has been observed in the placenta, and it has been shown to have a role in protecting the fetus from xenobiotics in the maternal circulation.

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Wikipedia