ABCG1

ABCG1
Identifiers
Aliases	ABCG1, ABC8, WHITE1, ATP binding cassette subfamily G member 1
External IDs	MGI: 107704 HomoloGene: 21022 GeneCards: ABCG1
Genetically Related Diseases
amyotrophic lateral sclerosis
Gene ontology Molecular function • nucleotide binding • protein dimerization activity • protein homodimerization activity • ADP binding • phospholipid transporter activity • sterol-transporting ATPase activity • cholesterol binding • ATPase activity • toxin transporter activity • protein binding • protein heterodimerization activity • phospholipid binding • ATP binding • cholesterol transporter activity • glycoprotein transporter activity Cellular component • integral component of membrane • recycling endosome • endosome • Golgi apparatus • endoplasmic reticulum membrane • membrane • Golgi membrane • plasma membrane • integral component of plasma membrane • endoplasmic reticulum • mitochondrion • external side of plasma membrane Biological process • lipoprotein metabolic process • phospholipid homeostasis • lipid transport • regulation of transcription, DNA-templated • detection of hormone stimulus • response to high density lipoprotein particle • phospholipid efflux • glycoprotein transport • cholesterol transport • cholesterol metabolic process • response to organic substance • high-density lipoprotein particle remodeling • negative regulation of cholesterol storage • response to lipid • intracellular cholesterol transport • low-density lipoprotein particle remodeling • positive regulation of cholesterol efflux • transmembrane transport • cholesterol efflux • transport • positive regulation of cholesterol biosynthetic process • negative regulation of lipid storage • cholesterol homeostasis • regulation of cholesterol esterification • negative regulation of macrophage derived foam cell differentiation • amyloid precursor protein catabolic process • reverse cholesterol transport • toxin transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9619	11307
Ensembl	ENSG00000160179	ENSMUSG00000024030
UniProt	P45844	Q64343
RefSeq (mRNA)	NM_004915 NM_016818 NM_207174 NM_207627 NM_207628 NM_207629 NM_207630	NM_009593
RefSeq (protein)	NP_004906 NP_058198 NP_997057 NP_997510 NP_997511 NP_997512	NP_033723.1
Location (UCSC)	Chr 21: 42.2 – 42.3 Mb	Chr 17: 31.06 – 31.12 Mb
PubMed search

9619

11307

ENSG00000160179

ENSMUSG00000024030

P45844

Q64343

NM_207629
NM_207630

NM_009593

NP_997512

NP_033723.1

ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene. It is a homolog of the well-known Drosophila gene white.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage, cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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