ABCC9

ABCC9
Identifiers
Aliases	ABCC9, ABC37, ATFB12, CANTU, CMD1O, SUR2, ATP binding cassette subfamily C member 9
External IDs	MGI: 1352630 HomoloGene: 56521 GeneCards: ABCC9
Genetically Related Diseases
obesity
Gene ontology Molecular function • nucleotide binding • ion channel binding • transporter activity • potassium channel regulator activity • sulfonylurea receptor activity • ATPase activity • ATP binding • ATPase-coupled anion transmembrane transporter activity • potassium channel activity • ATPase activity, coupled to transmembrane movement of substances Cellular component • integral component of membrane • membrane • voltage-gated potassium channel complex • plasma membrane • sarcomere • ATP-sensitive potassium channel complex • sarcolemma Biological process • regulation of cardiac conduction • potassium ion transport • defense response to virus • potassium ion import • transport • signal transduction • ATP hydrolysis coupled anion transmembrane transport • response to drug • transmembrane transport • regulation of molecular function Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10060	20928
Ensembl	ENSG00000069431	ENSMUSG00000030249
UniProt	O60706 Q8N4N7	P70170
RefSeq (mRNA)	NM_005691 NM_020297 NM_020298	NM_001044720 NM_011511 NM_021041 NM_021042 NM_021043 NM_001310143
RefSeq (protein)	NP_005682 NP_064693	NP_001038185.1 NP_035641.1 NP_066378.1 NP_066379.2 NP_001038185 NP_001297072 NP_035641 NP_066378 NP_066379
Location (UCSC)	Chr 12: 21.8 – 21.94 Mb	Chr 6: 142.59 – 142.7 Mb
PubMed search

10060

20928

ENSG00000069431

ENSMUSG00000030249

O60706
Q8N4N7

P70170

NM_005691
NM_020297
NM_020298

NM_001310143

NP_005682
NP_064693

NP_001297072
NP_035641
NP_066378
NP_066379

ATP-binding cassette, sub-family C member 9 (ABCC9) also known as sulfonylurea receptor 2 (SUR2) is an ATP-binding cassette transporter that in humans is encoded by the ABCC9 gene.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion.

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