ABCC5

ABCC5
Identifiers
Aliases	ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11, ATP binding cassette subfamily C member 5
External IDs	MGI: 1351644 HomoloGene: 21164 GeneCards: ABCC5
Gene location (Human) Chr. Chromosome 3 (human) Band 3q27.1 Start 183,919,934 bp End 184,018,015 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band n/a Start 20,331,303 bp End 20,426,394 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • organic anion transmembrane transporter activity • ATPase activity • ATP binding • ATPase-coupled anion transmembrane transporter activity • ATPase activity, coupled to transmembrane movement of substances Cellular component • integral component of membrane • plasma • integral component of plasma membrane • membrane Biological process • hyaluronan biosynthetic process • organic anion transport • ATP hydrolysis coupled anion transmembrane transport • transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10057	27416
Ensembl	ENSG00000114770	ENSMUSG00000022822
UniProt	O15440	Q9R1X5
RefSeq (mRNA)	NM_001023587 NM_005688 NM_001320032	NM_013790 NM_176839
RefSeq (protein)	NP_001018881 NP_001306961 NP_005679	NP_038818 NP_789809
Location (UCSC)	Chr 3: 183.92 – 184.02 Mb	Chr 3: 20.33 – 20.43 Mb
PubMed search

10057

27416

ENSG00000114770

ENSMUSG00000022822

O15440

Q9R1X5

NM_001023587
NM_005688
NM_001320032

NM_013790
NM_176839

NP_001018881
NP_001306961
NP_005679

NP_038818
NP_789809

Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

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Wikipedia