ABCC4

ABCC4
Identifiers
Aliases	ABCC4, MOAT-B, MOATB, MRP4, ATP binding cassette subfamily C member 4
External IDs	MGI: 2443111 HomoloGene: 74563 GeneCards: ABCC4
Gene location (Human) Chr. Chromosome 13 (human) Band 13q32.1 Start 95,019,829 bp End 95,301,446 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band n/a Start 118,482,692 bp End 118,706,219 bp
Gene ontology Molecular function • nucleotide binding • ATPase activity • ATP binding • 15-hydroxyprostaglandin dehydrogenase (NAD+) activity • ATPase-coupled anion transmembrane transporter activity • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism • ATPase activity, coupled to transmembrane movement of substances Cellular component • integral component of membrane • platelet dense granule membrane • membrane • plasma • basolateral plasma membrane • integral component of plasma membrane Biological process • prostaglandin secretion • platelet degranulation • response to drug • response to organic cyclic compound • oxidation-reduction process • response to organic substance • positive regulation of smooth muscle cell proliferation • response to organonitrogen compound • transmembrane transport • cilium morphogenesis • ATP hydrolysis coupled ion transmembrane transport • ATP hydrolysis coupled anion transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10257	239273
Ensembl	ENSG00000125257	ENSMUSG00000032849
UniProt	O15439	n/a
RefSeq (mRNA)	NM_001105515 NM_001301829 NM_001301830 NM_005845	NM_001033336 NM_001163675 NM_001163676
RefSeq (protein)	NP_001098985 NP_001288758 NP_001288759 NP_005836	n/a
Location (UCSC)	Chr 13: 95.02 – 95.3 Mb	Chr 13: 118.48 – 118.71 Mb
PubMed search

10257

239273

ENSG00000125257

ENSMUSG00000032849

O15439

n/a

NM_001105515
NM_001301829
NM_001301830
NM_005845

NM_001033336
NM_001163675
NM_001163676

NP_001098985
NP_001288758
NP_001288759
NP_005836

n/a

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.

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Wikipedia