ABCC3

ABCC3
Identifiers
Aliases	ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2, ATP binding cassette subfamily C member 3
External IDs	MGI: 1923658 HomoloGene: 68364 GeneCards: ABCC3
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.33 Start 50,634,777 bp End 50,692,252 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band n/a Start 94,343,295 bp End 94,392,997 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transporter activity • ATPase activity, coupled to transmembrane movement of substances • nucleotide binding • organic anion transmembrane transporter activity • ATPase activity • ATP binding • ATPase-coupled anion transmembrane transporter activity • bile acid-exporting ATPase activity • xenobiotic-transporting ATPase activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane • basolateral plasma membrane Biological process • transmembrane transport • bile acid and bile salt transport • ATP hydrolysis coupled anion transmembrane transport • drug transmembrane transport • xenobiotic transport • canalicular bile acid transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8714	76408
Ensembl	ENSG00000108846	ENSMUSG00000020865
UniProt	O15438	B2RX12
RefSeq (mRNA)	NM_001144070 NM_003786 NM_020037 NM_020038	NM_029600
RefSeq (protein)	NP_001137542 NP_003777	NP_083876
Location (UCSC)	Chr 17: 50.63 – 50.69 Mb	Chr 17: 94.34 – 94.39 Mb
PubMed search

8714

76408

ENSG00000108846

ENSMUSG00000020865

O15438

B2RX12

NM_001144070
NM_003786
NM_020037
NM_020038

NM_029600

NP_001137542
NP_003777

NP_083876

Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

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Wikipedia