ABCC11

ABCC11
Identifiers
Aliases	ABCC11, ATP-binding cassette, sub-family C (CFTR/MRP), member 11, EWWD, MRP8, WW, ATP binding cassette subfamily C member 11
External IDs	HomoloGene: 69511 GeneCards: ABCC11
Gene location (Human) Chr. Chromosome 16 (human) Band 16q12.1 Start 48,166,910 bp End 48,247,568 bp
Gene ontology Molecular function • nucleotide binding • organic anion transmembrane transporter activity • ATPase activity • ATP binding • purine nucleotide transmembrane transporter activity • ATPase-coupled anion transmembrane transporter activity • ATPase activity, coupled to transmembrane movement of substances Cellular component • integral component of membrane • integral component of plasma membrane • extracellular exosome • membrane • vacuole • vacuolar membrane • plasma • cytoplasmic vesicle membrane • cytoplasmic vesicle Biological process • purine nucleotide transport • transmembrane transport • organic anion transport • ATP hydrolysis coupled anion transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85320	n/a
Ensembl	ENSG00000121270	n/a
UniProt	Q96J66	n/a
RefSeq (mRNA)	NM_032583 NM_033151 NM_145186	n/a
RefSeq (protein)	NP_115972 NP_149163 NP_660187 NP_115972.2 NP_149163.2	n/a
Location (UCSC)	Chr 16: 48.17 – 48.25 Mb	n/a
PubMed search		n/a

85320

n/a

ENSG00000121270

n/a

Q96J66

n/a

NM_032583
NM_033151
NM_145186

n/a

NP_115972
NP_149163
NP_660187
NP_115972.2
NP_149163.2

n/a

ATP-binding cassette transporter sub-family C member 11 is a protein that in humans is encoded by the ABCC11 gene.

The gene is responsible for determination of human cerumen type (wet or dry ear wax) and presence of underarm osmidrosis (odor associated with sweat caused by excessive apocrine secretion).

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type and presence of underarm odour. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.

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Wikipedia