ABCC10

ABCC10
Identifiers
Aliases	ABCC10, EST182763, MRP7, SIMRP7, ATP binding cassette subfamily C member 10
External IDs	MGI: 2386976 HomoloGene: 58616 GeneCards: ABCC10
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.1 Start 43,427,366 bp End 43,450,430 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band n/a Start 46,303,221 bp End 46,328,352 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • ATPase activity • ATP binding • ATPase-coupled anion transmembrane transporter activity • ATPase activity, coupled to transmembrane movement of substances Cellular component • integral component of membrane • lysosomal membrane • plasma • membrane • integral component of plasma membrane Biological process • ATP hydrolysis coupled anion transmembrane transport • transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	89845	224814
Ensembl	ENSG00000124574	ENSMUSG00000032842
UniProt	Q5T3U5	Q8R4P9
RefSeq (mRNA)	NM_001198934 NM_033450 NM_001350518	NM_145140 NM_170680 NM_001347396
RefSeq (protein)	NP_001185863 NP_258261 NP_001337447	NP_001334325 NP_660122 NP_733780
Location (UCSC)	Chr 6: 43.43 – 43.45 Mb	Chr 6: 46.3 – 46.33 Mb
PubMed search

89845

224814

ENSG00000124574

ENSMUSG00000032842

Q5T3U5

Q8R4P9

NM_001198934
NM_033450
NM_001350518

NM_145140
NM_170680
NM_001347396

NP_001185863
NP_258261
NP_001337447

NP_001334325
NP_660122
NP_733780

Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.

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