ABCC1

ABCC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CBZ, 4C3Z
Identifiers
Aliases	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1, ATP binding cassette subfamily C member 1
External IDs	MGI: 102676 HomoloGene: 133779 GeneCards: ABCC1
Gene ontology Molecular function • ATPase activity, coupled to transmembrane movement of substances • nucleotide binding • ATPase activity • hydrolase activity • ATP binding • transporter activity • ATPase-coupled anion transmembrane transporter activity • cobalamin-transporting ATPase activity • xenobiotic-transporting ATPase activity • glutathione S-conjugate-exporting ATPase activity • glutathione transmembrane transporter activity Cellular component • integral component of membrane • plasma membrane • basolateral plasma membrane • membrane • extracellular exosome • integral component of plasma membrane Biological process • cobalamin metabolic process • leukotriene metabolic process • response to drug • transmembrane transport • transport • cobalamin transport • vitamin transmembrane transport • ATP hydrolysis coupled anion transmembrane transport • drug transmembrane transport • glutathione transmembrane transport • xenobiotic transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4363	17250
Ensembl	n/a	ENSMUSG00000023088
UniProt	P33527	O35379
RefSeq (mRNA)	NM_004996 NM_019862 NM_019898 NM_019899 NM_019900 NM_019901 NM_019902	NM_008576
RefSeq (protein)	NP_004987	NP_032602.1 NP_032602
Location (UCSC)	Chr 16: 15.95 – 16.14 Mb	Chr 16: 14.36 – 14.48 Mb
PubMed search

2CBZ, 4C3Z

4363

17250

n/a

ENSMUSG00000023088

P33527

O35379

NM_019901
NM_019902

NM_008576

NP_004987

NP_032602.1
NP_032602

Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.

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