ABCB8

ABCB8
Identifiers
Aliases	ABCB8, EST328128, M-ABC1, MABC1, ATP binding cassette subfamily B member 8
External IDs	MGI: 1351667 HomoloGene: 5203 GeneCards: ABCB8
Gene location (Human) Chr. Chromosome 7 (human) Band 7q36.1 Start 151,028,422 bp End 151,047,782 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band n/a Start 24,393,663 bp End 24,410,054 bp
Gene ontology Molecular function • transporter activity • ATPase activity • ATP binding • nucleotide binding • ATPase activity, coupled to transmembrane movement of substances Cellular component • integral component of membrane • mitochondrial envelope • ATP-binding cassette (ABC) transporter complex • nucleus • nucleolus • mitochondrion • mitochondrial inner membrane • membrane Biological process • transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11194	74610
Ensembl	ENSG00000197150	ENSMUSG00000028973
UniProt	Q9NUT2	Q9CXJ4
RefSeq (mRNA)	NM_007188 NM_001282291 NM_001282292 NM_001282293	NM_029020
RefSeq (protein)	NP_001269220 NP_001269221 NP_001269222 NP_009119	NP_083296
Location (UCSC)	Chr 7: 151.03 – 151.05 Mb	Chr 7: 24.39 – 24.41 Mb
PubMed search

11194

74610

ENSG00000197150

ENSMUSG00000028973

Q9NUT2

Q9CXJ4

NM_007188
NM_001282291
NM_001282292
NM_001282293

NM_029020

NP_001269220
NP_001269221
NP_001269222
NP_009119

NP_083296

ATP-binding cassette sub-family B member 8, mitochondrial is a protein that in humans is encoded by the ABCB8 gene.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes.

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Wikipedia