ABCB6

ABCB6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NH6, 3NH9, 3NHA, 3NHB
Identifiers
Aliases	ABCB6, ABC, ABC14, DUH3, LAN, MCOPCB7, MTABC3, PRP, umat, PSHK2, ATP binding cassette subfamily B member 6 (Langereis blood group)
External IDs	MGI: 1921354 HomoloGene: 11375 GeneCards: ABCB6
Gene ontology Molecular function • ATPase activity, coupled to transmembrane movement of substances • nucleotide binding • heme transporter activity • heme-transporting ATPase activity • ATPase activity • heme binding • efflux transmembrane transporter activity • ATP binding Cellular component • integral component of membrane • endosome • Golgi apparatus • endoplasmic reticulum membrane • membrane • ATP-binding cassette (ABC) transporter complex • Golgi membrane • plasma membrane • integral component of mitochondrial outer membrane • mitochondrial outer membrane • endoplasmic reticulum • mitochondrion • mitochondrial envelope • endosome membrane • extracellular exosome • nucleoplasm • cytosol Biological process • porphyrin-containing compound biosynthetic process • heme transport • brain development • transmembrane transport • transport • skin development • cellular iron ion homeostasis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10058	74104
Ensembl	ENSG00000115657	ENSMUSG00000026198
UniProt	Q9NP58	Q9DC29
RefSeq (mRNA)	NM_005689 NM_001349828	NM_023732
RefSeq (protein)	NP_005680 NP_001336757	NP_076221.1 NP_076221
Location (UCSC)	Chr 2: 219.21 – 219.22 Mb	Chr 1: 75.17 – 75.18 Mb
PubMed search

3NH6, 3NH9, 3NHA, 3NHB

10058

74104

ENSG00000115657

ENSMUSG00000026198

Q9NP58

Q9DC29

NM_005689
NM_001349828

NM_023732

NP_005680
NP_001336757

NP_076221.1
NP_076221

ATP-binding cassette sub-family B member 6, mitochondrial is a protein that in humans is encoded by the ABCB6 gene.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for Dyschromatosis Universalis Hereditaria, a disorder of skin pigment metabolism.

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Wikipedia