ABCB4

ABCB4
Identifiers
Aliases	ABCB4, ABC21, GBD1, ICP3, MDR2, MDR2/3, MDR3, PFIC-3, PGY3, ATP binding cassette subfamily B member 4
External IDs	OMIM: 171060 MGI: 97569 HomoloGene: 136368 GeneCards: ABCB4
EC number	3.6.3.44
Gene ontology Molecular function • ATPase activity, coupled to transmembrane movement of substances • nucleotide binding • xenobiotic-transporting ATPase activity • phosphatidylcholine transporter activity • phosphatidylcholine-translocating ATPase activity • ATPase activity • protein binding • hydrolase activity • ATP binding • phospholipid transporter activity • ceramide-translocating ATPase activity Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • intercellular canaliculus • apical plasma membrane • membrane raft • extracellular exosome • cytoplasmic vesicle • clathrin-coated vesicle • nucleoplasm • cytosol • focal adhesion • actin cytoskeleton • brush border membrane • apical part of cell Biological process • lipid transport • cellular response to bile acid • positive regulation of cholesterol transport • positive regulation of phospholipid translocation • drug transmembrane transport • lipid metabolic process • positive regulation of phospholipid transport • response to fenofibrate • xenobiotic transport • transmembrane transport • lipid homeostasis • bile acid secretion • transport • phospholipid translocation • response to hypoxia • placenta development • brain development • lactation • circadian rhythm • hormone transport • response to organic substance • response to mycotoxin • response to organic cyclic compound • response to isoquinoline alkaloid • response to nutrient levels • response to estradiol • response to vitamin A • carbohydrate export • response to vitamin D • maintenance of permeability of blood-brain barrier • cellular response to mycotoxin • response to drug • daunorubicin transport • response to morphine • drug export • response to cadmium ion • intestinal absorption • negative regulation of cell death • establishment of blood-brain barrier • cellular response to external biotic stimulus • cellular response to antibiotic • cellular response to alkaloid • cellular response to estradiol stimulus • cellular response to organic cyclic compound • cellular hyperosmotic salinity response • response to dexamethasone • cellular response to dexamethasone stimulus • response to thyroxine • response to antineoplastic agent • ceramide translocation • response to L-glutamate • response to glycoside • cellular response to borneol • cellular response to L-glutamate • response to codeine • response to quercetin • response to cyclosporin A • drug transport across blood-brain barrier • establishment of blood-retinal barrier • positive regulation of response to drug • regulation of lipid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5244	18670
Ensembl	ENSG00000005471	ENSMUSG00000042476
UniProt	P21439	P21440
RefSeq (mRNA)	NM_000443 NM_018849 NM_018850	NM_008830
RefSeq (protein)	NP_000434 NP_061337 NP_061338	NP_032856.2 NP_032856
Location (UCSC)	Chr 7: 87.4 – 87.48 Mb	Chr 5: 8.89 – 8.96 Mb
PubMed search

5244

18670

ENSG00000005471

ENSMUSG00000042476

P21439

P21440

NM_000443
NM_018849
NM_018850

NM_008830

NP_000434
NP_061337
NP_061338

NP_032856.2
NP_032856

Multidrug resistance protein 3 is a protein that in humans is encoded by the ABCB4 gene. ABCB4 is associated with progressive familial intrahepatic cholestasis type 3.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate (flippase activity). The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.

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