ABCA12

ABCA12
Identifiers
Aliases	ABCA12, ARCI4A, ARCI4B, ICR2B, LI2, ATP binding cassette subfamily A member 12
External IDs	MGI: 2676312 HomoloGene: 45441 GeneCards: ABCA12
Gene ontology Molecular function • ATPase activity, coupled to transmembrane movement of substances • nucleotide binding • transporter activity • apolipoprotein A-I receptor binding • ATPase activity • protein binding • receptor binding • ATP binding • lipid-transporting ATPase activity • lipid transporter activity Cellular component • cytoplasm • integral component of membrane • cytosol • membrane • plasma membrane • mitochondrial inner membrane • epidermal lamellar body Biological process • surfactant homeostasis • lipid transport • ceramide transport • establishment of skin barrier • secretion by cell • phospholipid efflux • keratinization • cellular homeostasis • keratinocyte differentiation • positive regulation of cholesterol efflux • transmembrane transport • positive regulation of protein localization to cell surface • lipid homeostasis • transport • regulated exocytosis • lung alveolus development • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26154	74591
Ensembl	ENSG00000144452	ENSMUSG00000050296
UniProt	Q86UK0	n/a
RefSeq (mRNA)	NM_015657 NM_173076	NM_175210
RefSeq (protein)	NP_056472 NP_775099	n/a
Location (UCSC)	Chr 2: 214.93 – 215.14 Mb	Chr 1: 71.24 – 71.41 Mb
PubMed search

26154

74591

ENSG00000144452

ENSMUSG00000050296

Q86UK0

n/a

NM_015657
NM_173076

NM_175210

NP_056472
NP_775099

n/a

ATP-binding cassette sub-family A member 12 also known as ATP-binding cassette transporter 12 is a protein that in humans is encoded by the ABCA12 gene.

ABCA12 belongs to a group of genes called the ATP-binding cassette family, which makes proteins that transport molecules across cell membranes. The ABCA12 gene is active in some types of skin cells and in several other tissues, such as testis, placenta, lung, stomach, and fetal brain and liver. This protein appears to be essential for normal development of the skin, which provides a barrier between the body and its surrounding environment. It transports epidermoside, a glucosylceramide, out of the keratinocytes of the stratum corneum of the epidermis.

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