A4GALT

A4GALT
Identifiers
Aliases	A4GALT, A14GALT, A4GALT1, Gb3S, P(k), P1, P1PK, PK, alpha 1,4-galactosyltransferase, alpha 1,4-galactosyltransferase (P blood group)
External IDs	MGI: 3512453 HomoloGene: 9690 GeneCards: A4GALT
EC number	2.4.1.228
Gene ontology Molecular function • transferase activity • lactosylceramide 4-alpha-galactosyltransferase activity • galactosyltransferase activity • toxic substance binding • transferase activity, transferring glycosyl groups Cellular component • integral component of membrane • integral component of Golgi membrane • Golgi membrane • Golgi apparatus • extracellular exosome • membrane Biological process • glycosphingolipid biosynthetic process • globoside biosynthetic process • protein glycosylation • plasma membrane organization • lipid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	53947	239559
Ensembl	ENSG00000128274	ENSMUSG00000047878
UniProt	Q9NPC4	Q67BJ4
RefSeq (mRNA)	NM_017436 NM_001318038	NM_001004150 NM_001170954
RefSeq (protein)	NP_001304967 NP_059132	NP_001004150.1 NP_001164425.1 NP_001004150 NP_001164425
Location (UCSC)	Chr 22: 42.69 – 42.72 Mb	Chr 15: 83.23 – 83.25 Mb
PubMed search

53947

239559

ENSG00000128274

ENSMUSG00000047878

Q9NPC4

Q67BJ4

NM_017436
NM_001318038

NM_001004150
NM_001170954

NP_001304967
NP_059132

NP_001004150.1
NP_001164425.1
NP_001004150
NP_001164425

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.

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