4'-hydroxynorendoxifen

4'-Hydroxynorendoxifen

Identifiers
IUPAC name 4,4'-(1-(4-(2-Aminoethoxy)phenyl)but-1-ene-1,2-diyl)diphenol
Synonyms	N,N-Didesmethyl-4,4'-dihydroxytamoxifen
ChemSpider	58967386
Chemical and physical data
Formula	C24H25NO3
Molar mass	375.47 g·mol−1
3D model (Jmol)	Interactive image
SMILES CCC(=C(C1=CC=C(O)C=C1)C1=CC=C(OCCN)C=C1)C1=CC=C(O)C=C1
InChI InChI=1S/C24H25NO3/c1-2-23(17-3-9-20(26)10-4-17)24(18-5-11-21(27)12-6-18)19-7-13-22(14-8-19)28-16-15-25/h3-14,26-27H,2,15-16,25H2,1H3 Key:VYSGWFCGFKTGQC-UHFFFAOYSA-N

4'-Hydroxynorendoxifen is a synthetic, non-steroidal antiestrogen of the triphenylethylene group. It is a dual selective estrogen receptor modulator (SERM) and aromatase inhibitor (AI), and was derived from tamoxifen, a SERM, and norendoxifen, a metabolite of tamoxifen that has been found to act as an AI. The drug has been suggested for potential development as a treatment for estrogen receptor (ER)-positive breast cancer. It was synthesized in 2015.