3-dehydroquinate dehydratase
| 3-dehydroquinate dehydratase | |||||||||
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The third step of the shikimate pathway is catalyzed by DHQD
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| Identifiers | |||||||||
| EC number | 4.2.1.10 | ||||||||
| CAS number | 9012-66-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Search | |
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
| Type I 3-dehydroquinase | |||||||||
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The structure of type i 3-dehydroquinate dehydratase from salmonella typhi
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| Identifiers | |||||||||
| Symbol | DHquinase_I | ||||||||
| Pfam | PF01487 | ||||||||
| Pfam clan | CL0036 | ||||||||
| InterPro | IPR001381 | ||||||||
| PROSITE | PDOC00789 | ||||||||
| SCOP | 2dhq | ||||||||
| SUPERFAMILY | 2dhq | ||||||||
| CDD | cd00502 | ||||||||
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| Available protein structures: | |
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| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
| Dehydroquinase class II | |||||||||
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| Identifiers | |||||||||
| Symbol | DHquinase_II | ||||||||
| Pfam | PF01220 | ||||||||
| PROSITE | PDOC00789 | ||||||||
| SCOP | 2dhq | ||||||||
| SUPERFAMILY | 2dhq | ||||||||
| CDD | cd00466 | ||||||||
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| Available protein structures: | |
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| Pfam | structures |
| PDB | RCSB PDB; PDBe; PDBj |
| PDBsum | structure summary |
In enzymology, a 3-dehydroquinate dehydratase (EC 4.2.1.10) is an enzyme that catalyzes the chemical reaction
Hence, this enzyme has one substrate, 3-dehydroquinate, and two products, 3-dehydroshikimate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.
The shikimate pathway was determined to be a major biosynthetic route for the production of aromatic amino acids through the research of Bernhard Davis and David Sprinson.
3-Dehydroquinate Dehydratase is an enzyme that catalyzes the third step of the shikimate pathway. The shikimate pathway is a biosynthetic pathway that allows plants, fungi, and bacteria to produce aromatic amino acids. Mammals do not have this pathway, meaning that they must obtain these essential amino acids through their diet. Aromatic Amino acids include Phenylalanine, Tyrosine, and Tryptophan.
This enzyme dehydrates 3-Dehydroquinate, converting it to 3-Dehydroshikimate, as indicated in the diagram on the right. This is the third step in the Shikimate pathway. It belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming). This enzyme is one of the few examples of convergent evolution. The two separate versions of this enzyme have different amino acid sequences.
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