25-hydroxyvitamin D3 1-alpha-hydroxylase

CYP27B1
Identifiers
Aliases	CYP27B1, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, cytochrome P450 family 27 subfamily B member 1
External IDs	OMIM: 609506 MGI: 1098274 HomoloGene: 37139 GeneCards: CYP27B1
EC number	1.14.13.13
Gene ontology Molecular function • iron ion binding • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • calcidiol 1-monooxygenase activity Cellular component • cytoplasm • membrane • mitochondrial membrane • mitochondrial outer membrane • mitochondrion Biological process • bone mineralization • response to vitamin D • calcium ion homeostasis • response to interferon-gamma • vitamin D metabolic process • regulation of bone mineralization • positive regulation of keratinocyte differentiation • G1 to G0 transition • response to estrogen • response to lipopolysaccharide • negative regulation of calcidiol 1-monooxygenase activity • decidualization • vitamin metabolic process • negative regulation of cell growth • calcitriol biosynthetic process from calciol • positive regulation of vitamin D 24-hydroxylase activity • vitamin D catabolic process • positive regulation of vitamin D receptor signaling pathway • oxidation-reduction process • calcium ion transport • negative regulation of cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1594	13115
Ensembl	ENSG00000111012	ENSMUSG00000006724
UniProt	O15528	O35084
RefSeq (mRNA)	NM_000785	NM_010009
RefSeq (protein)	NP_000776	NP_034139.2 NP_034139
Location (UCSC)	Chr 12: 57.76 – 57.77 Mb	Chr 10: 127.05 – 127.05 Mb
PubMed search

calcidiol 1-monooxygenase
Identifiers
EC number	1.14.15.18
CAS number	9081-36-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

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PMC	articles
PubMed	articles
NCBI	proteins

1594

13115

ENSG00000111012

ENSMUSG00000006724

O15528

O35084

NM_000785

NM_010009

NP_000776

NP_034139.2
NP_034139

25-Hydroxyvitamin D₃ 1-alpha-hydroxylase (VD3 1A hydroxylase) also known as cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a enzyme that in humans is encoded by the CYP27B1 gene.

VD3 1A hydroxylase is located in the proximal tubule of the kidney and a variety of other tissues, including skin (keratinocytes), immune cells, and bone (osteoblasts). The enzyme catalyzes the hydroxylation of Calcifediol to calcitriol (the bioactive form of Vitamin D):

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