2016 Western & Southern Open – Women's Singles
| Women's Singles | |
|---|---|
| 2016 Western & Southern Open | |
| Champion |
 Karolína Plíšková
|
| Runner-up |
 Angelique Kerber
|
| Final score | 6–3, 6–1 |
Serena Williams was the two-time defending champion, but withdrew before the tournament began due to injury.
Angelique Kerber was in contention for the world No. 1 ranking, which she would have attained had she won the title. However, by losing in the final she remained No. 2.
Karolína Plíšková won her sixth WTA singles title, defeating Kerber in the final, 6–3, 6–1.
The two would play each other three weeks later, in the final of the US Open. Having already claimed the No. 1 ranking following Williams' defeat in the semifinals, Kerber avenged her loss by beating Plíšková in three sets.
All seeds received a bye into the second round.
Click on the seed number of a player to go to their draw section.
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