2016 Mutua Madrid Open – Women's Singles
| Women's Singles | |
|---|---|
| 2016 Mutua Madrid Open | |
| Champion |
 Simona Halep
|
| Runner-up |
 Dominika Cibulková
|
| Final score | 6–2, 6–4 |
Petra Kvitová was the defending champion, but lost in the third round to Daria Gavrilova.
Simona Halep won the title, defeating Dominika Cibulková in the final, 6–2, 6–4.
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