2016 Internazionali BNL d'Italia – Women's Singles
| Women's Singles | |
|---|---|
| 2016 Internazionali BNL d'Italia | |
| Champion |
 Serena Williams
|
| Runner-up |
Madison Keys
|
| Final score | 7–6(7–5), 6–3 |
Maria Sharapova was the defending champion, but could not defend the title because of her provisional suspension after failing a drug test at the Australian Open.
Serena Williams won the title, defeating Madison Keys in the final, 7–6(7–5), 6–3.
The top eight seeds received a bye into the second round.
Click on the seed number of a player to go to their draw section.
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