The 2016 CAF Champions League Final was the final of the 2016 CAF Champions League, the 52nd edition of Africa's premier club football tournament organized by the Confederation of African Football (CAF), and the 20th edition under the current CAF Champions League format.

The final was contested in two-legged home-and-away format between Mamelodi Sundowns of South Africa and Zamalek of Egypt. The first leg was hosted by Mamelodi Sundowns at the Lucas Masterpieces Moripe Stadium in Pretoria on 15 October 2016, while the second leg was hosted by Zamalek at the Borg El Arab Stadium in Alexandria on 23 October 2016. The winner earned the right to represent the CAF at the 2016 FIFA Club World Cup, entering at the quarterfinal stage, as well as play in the 2017 CAF Super Cup against the winner of the 2016 CAF Confederation Cup.

Mamelodi Sundowns defeated Zamalek 3–1 on aggregate to win the competition for the first time in its history.

Note: In all results below, the score of the finalist is given first (H: home; A: away).

The final was played on a home-and-away two-legged basis. If the aggregate score was tied after the second leg, the away goals rule would be applied, and if still tied, extra time would not be played, and the penalty shoot-out would be used to determine the winner (Regulations III. 26 & 27).

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