2012 Western & Southern Open – Men's Singles
| Men's Singles | |
|---|---|
| 2012 Western & Southern Open | |
| Champion |
 Roger Federer
|
| Runner-up |
 Novak Djokovic
|
| Final score | 6–0, 7–6 (9–7) |
| Draw | 56 |
| Seeds | 16 |
Andy Murray was the defending champion, but lost in the third round to lucky loser Jérémy Chardy.
World No. 1 Roger Federer won his record fifth title at the Cincinnati Masters defeating 3-time runner-up and World No. 2 Novak Djokovic 6–0, 7–6 (9–7). Federer also set a new record by not having serve broken or losing a set for the first time in the history of any Masters 1000 tournament. He would repeat this accomplishment at the 2015 Cincinnati Masters.
The top eight seeds receive a bye into the second round.
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