The 2012–13 Spartak Moscow season was the club's 21st season in the Russian Premier League, the highest tier of association football in Russia. They finished the season in fourth place, qualifying for the UEFA Europa League; reached the round of 16 in the Russian Cup; and were knocked out 2012–13 UEFA Champions League at the group stage.

Spartak started the season under the management of Unai Emery, who they appointed as manager in June 2012 after Valery Karpin resigned following the completion of the previous season. Emery lasted five months before being sacked on 25 November, and Karpin was appointed caretaker manager before being handed the job permanently on 13 December 2012.

Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

The following players are listed by Spartak's website as reserve players and are registered with the Premier League. They are eligible to play for the first team.

Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

In: Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

Out: Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

In: Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

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