2011 Winston-Salem Open – Singles
| Singles | |
|---|---|
| 2011 Winston-Salem Open | |
| Champion |
 John Isner
|
| Runner-up |
 Julien Benneteau
|
| Final score | 4–6, 6–3, 6–4 |
Sergiy Stakhovsky was the defending champion, but lost to Julien Benneteau in the quarterfinals. John Isner defeated Benneteau in the final, 4–6, 6–3, 6–4.
All seeds received a bye into the second round.
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